Heparin Induced Trombocytopenia

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Happens more frequently as we use more Heparin (HIT)
Heparin is produced from the intestines in Pigs and Buffalo

In patients using Heparin they get increased

  • Aminotrasferase - (this is not liver dysfunction)
  • HyperKalemia (Potassium level goes up)

Platelet count drops to upto 50%

    • Immune mediated, 
    • Ab recognizes the a complex of heparin and platelet factor 4 (PF4) leading to platelet activation via platelet Fc receptor and activation of the coagulation system


Pathophysiology:



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