Growth Hormone
Promotion of Linear Growth - Stimulates the eppheseal Cartilage of the long bones Promotion of protein deposition in tissues Promotion of Fat utilisation for Energy - mobilisation of FFA from adipose tissue and the peripheral utilisation of FFA for Energy Impairment of carbohydrate utilisation for energy - Decreases uptake and utilisation of Glucose by many insulin sensitive cells, such as muscle and adipose tissue. Increase Glucose and there is a compensatory increase in Insulin. GH is diabetogenic Promotes the secretion of Somatomedins or IGF's - secreted by the liver - and the growth promoting effects are due to locally produced and circulating somatomedins in cartilage and muscle. Locally produced somatomedins act in a autocrine or paracrine fashion Hypothalamus - GHRH stimulates and Somatostatin inhibits - GH Three general catagories that increase GH secretion: Fasting, Chronic protein deprevation, or a fall in plasma glucose and FFA Increased plasma levels of amino a